Keywords |
qi chen lab, qi chen, University of Utah School of Medicine, qichen, sperm samll RNAs, sperm tsRNA, rsRNAs, sperm tsRNAs, tRFs, tRNA-dervied small RNAs, serum, serum tsRNAs, transgenerational epigenetic inheritance, intergenerational inheritance, non-coding RNAs, embryo development, early embryo symmetry-breaking, bistable, monostable, small biases, AQP3, AQP4, AQP5, aquaporin-3, sperm osmoadaptation, sperm osmoregulation, RVD, mechanosensor, osmosensor, mechanosensing, mechxnosensitive, evolution
Previous at University of Nevada, Reno; University of California, Riverside
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Description |
Dr. Qi Chen is a reproductive & developmental biologist at University of Utah School of Medicine
We study sperm RNAs and their roles in mediating intergenerational and transgenerational epigenetic inheritance.
We are also interested in studying the molecular mechanisms of Symmetry-breaking in mammalian early embryo.
Our recent works focus on sperm tsRNAs (tRNA-derived small RNAs), rsRNAs (rRNA-derived small RNAs) and its role in epigenetic memory, showing that sperm tsRNAs act as a type of paternal epigetic factor that contribute to intergenerational inheritance of an acquired metabolic disorder.
Research from his lab add to the growing body of inheritable factors beyond DNA sequences, leading to a resurrected lamarckism, that inheritance of acquired characteristics during environmental exposure do happens under epigenetic regulations.
Website: http://qichen-lab.info/
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